In silico Medicinal Chemist at MRC Technology
- London, United Kingdom
Chido Mpamhanga's Overview
- In silico Medicinal Chemist at MRC Technology
- IUPHAR-Database at University of Edinburgh
- PostDoc Computational Chemistry at University of Dundee
- Compchem PhD Student at GSK
- The University of Sheffield
Chido Mpamhanga's Experience
In silico Medicinal Chemist
Nonprofit; 51-200 employees; Research industry
July 2011 – Present (2 years)
- supporting early drug discovery projects;
- developing tools and methods for lead discovery and lead development
Educational Institution; 5001-10,000 employees; Research industry
April 2009 – June 2012 (3 years 3 months)
PostDoc Computational Chemistry
Educational Institution; 1001-5000 employees; Research industry
2007 – 2009 (2 years)
Compchem PhD Student
Public Company; 10,001+ employees; GSK; Pharmaceuticals industry
2005 – 2006 (1 year)
Chido Mpamhanga's Publications
Authors: Chido Mpamhanga, Mpamhanga CP Sharman JL Harmar AJ NC-IUPHAR.
Authors: Chido Mpamhanga, Cleghorn LA Woodland A Collie IT Torrie LS Norcross N Luksch T Mpamhanga C Walker RG Mottram JC Brenk
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.
Authors: Chido Mpamhanga, Spinks D Ong HB Mpamhanga CP Shanks EJ Robinson DA Collie IT Read KD Frearson JA Wyatt PG Brenk R Fa
- Nucleic Acids Res.
- January 2011
- April 2010
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.
- J Med Chem
- July 2010
Knowledge-based interaction fingerprint scoring: a simple method for improving the effectiveness of fast scoring functions.
- J Chem Inf Model
- April 2010
Retrospective docking study of PDE4B ligands and an analysis of the behavior of selected scoring functions.
- J Chem Inf Model
- July 2005
Authors: Chido Mpamhanga, Anthony Harmar, Jo Sharman, Helen Benson, Adam Pawson, Veny Lukito, Vincent Bombail, Anthony Davenport, John Peters, Michael Spedding
- Nucl. Acids Res.
A summary of recent updates and new features added to the IUPHAR database over the past 2 years.
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Authors: Chido Mpamhanga, Davenport A.P., Jo Sharman, Anthony Harmar, Steve Alexander, Bonner T.I., Neubig R.R., Pin J.P., Spedding M., Helen Benson, Pawson A.J.
- Pharmacological Reviews
- May 17, 2013
In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human gene sequences known or predicted to encode G protein-coupled receptors (GPCRs), excluding sensory receptors. This review updates the list of orphan GPCRs and describes the criteria used by NC-IUPHAR to recommend the pairing of an orphan receptor with its cognate ligand(s). The following recommendations are made for new receptor names based on 11 pairings for class A GPCRs: hydroxycarboxylic acid receptors [HCA₁ (GPR81) with lactate, HCA₂ (GPR109A) with 3-hydroxybutyric acid, HCA₃ (GPR109B) with 3-hydroxyoctanoic acid]; lysophosphatidic acid receptors [LPA₄ (GPR23), LPA₅ (GPR92), LPA₆ (P2Y5)]; free fatty acid receptors [FFA4 (GPR120) with omega-3 fatty acids]; chemerin receptor (CMKLR1; ChemR23) with chemerin; CXCR7 (CMKOR1) with chemokines CXCL12 (SDF-1) and CXCL11 (ITAC); succinate receptor (SUCNR1) with succinate; and oxoglutarate receptor [OXGR1 with 2-oxoglutarate]. Pairings are highlighted for an additional 30 receptors in class A where further input is needed from the scientific community to validate these findings. Fifty-seven human class A receptors (excluding pseudogenes) are still considered orphans; information has been provided where there is a significant phenotype in genetically modified animals. In class B, six pairings have been reported by a single publication, with 28 (excluding pseudogenes) still classified as orphans. Seven orphan receptors remain in class C, with one pairing described by a single paper. The objective is to stimulate research into confirming pairings of orphan receptors where there is currently limited information and to identify cognate ligands for the remaining GPCRs. Further information can be found on the IUPHAR Database website (http://www.iuphar-db.org).
Chido Mpamhanga's Skills & Expertise
Chido Mpamhanga's Education
The University of Sheffield
PhD, MSc, Computational Chemistry/Chemoinformatics
2002 – 2006
Chido Mpamhanga's Additional Information
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