Chido Mpamhanga
In silico Medicinal Chemist at MRC Technology
- Location
- London, United Kingdom
- Industry
- Pharmaceuticals
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Chido Mpamhanga's Overview
- Current
-
- In silico Medicinal Chemist at MRC Technology
- Past
-
- IUPHAR-Database at University of Edinburgh
- PostDoc Computational Chemistry at University of Dundee
- Compchem PhD Student at GSK
- Education
-
- The University of Sheffield
- Connections
-
128 connections
Chido Mpamhanga's Experience
In silico Medicinal Chemist
MRC Technology
Nonprofit; 51-200 employees; Research industry
July 2011 – Present (2 years)
Computational chemistry:-
- supporting early drug discovery projects;
- developing tools and methods for lead discovery and lead development
IUPHAR-Database
University of Edinburgh
Educational Institution; 5001-10,000 employees; Research industry
April 2009 – June 2012 (3 years 3 months)
PostDoc Computational Chemistry
University of Dundee
Educational Institution; 1001-5000 employees; Research industry
2007 – 2009 (2 years)
Compchem PhD Student
GSK
Public Company; 10,001+ employees; GSK; Pharmaceuticals industry
2005 – 2006 (1 year)
Chido Mpamhanga's Publications
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How to Use the IUPHAR Receptor Database to Navigate Pharmacological Data.
- SpringerLink
- 2012
Authors: Chido Mpamhanga, Mpamhanga CP Sharman JL Harmar AJ NC-IUPHAR. -
Identification of inhibitors of the Leishmania cdc2-related protein kinase CRK3.
- ChemMedChem
- 2011
Authors: Chido Mpamhanga, Cleghorn LA Woodland A Collie IT Torrie LS Norcross N Luksch T Mpamhanga C Walker RG Mottram JC Brenk -
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.
- ChemMedChem
- 2011
Authors: Chido Mpamhanga, Spinks D Ong HB Mpamhanga CP Shanks EJ Robinson DA Collie IT Read KD Frearson JA Wyatt PG Brenk R Fa -
IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data.
- Nucleic Acids Res.
- January 2011
Authors: Chido Mpamhanga -
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
- Nature
- April 2010
Authors: Chido Mpamhanga -
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.
- J Med Chem
- July 2010
Authors: Chido Mpamhanga -
Knowledge-based interaction fingerprint scoring: a simple method for improving the effectiveness of fast scoring functions.
- J Chem Inf Model
- April 2010
Authors: Chido Mpamhanga -
Retrospective docking study of PDE4B ligands and an analysis of the behavior of selected scoring functions.
- J Chem Inf Model
- July 2005
Authors: Chido Mpamhanga -
IUPHAR-DB: updated database content and new features
- Nucl. Acids Res.
Authors: Chido Mpamhanga, Anthony Harmar, Jo Sharman, Helen Benson, Adam Pawson, Veny Lukito, Vincent Bombail, Anthony Davenport, John Peters, Michael SpeddingA summary of recent updates and new features added to the IUPHAR database over the past 2 years.
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International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
- Pharmacological Reviews
- May 17, 2013
Authors: Chido Mpamhanga, Davenport A.P., Jo Sharman, Anthony Harmar, Steve Alexander, Bonner T.I., Neubig R.R., Pin J.P., Spedding M., Helen Benson, Pawson A.J.In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human gene sequences known or predicted to encode G protein-coupled receptors (GPCRs), excluding sensory receptors. This review updates the list of orphan GPCRs and describes the criteria used by NC-IUPHAR to recommend the pairing of an orphan receptor with its cognate ligand(s). The following recommendations are made for new receptor names based on 11 pairings for class A GPCRs: hydroxycarboxylic acid receptors [HCA₁ (GPR81) with lactate, HCA₂ (GPR109A) with 3-hydroxybutyric acid, HCA₃ (GPR109B) with 3-hydroxyoctanoic acid]; lysophosphatidic acid receptors [LPA₄ (GPR23), LPA₅ (GPR92), LPA₆ (P2Y5)]; free fatty acid receptors [FFA4 (GPR120) with omega-3 fatty acids]; chemerin receptor (CMKLR1; ChemR23) with chemerin; CXCR7 (CMKOR1) with chemokines CXCL12 (SDF-1) and CXCL11 (ITAC); succinate receptor (SUCNR1) with succinate; and oxoglutarate receptor [OXGR1 with 2-oxoglutarate]. Pairings are highlighted for an additional 30 receptors in class A where further input is needed from the scientific community to validate these findings. Fifty-seven human class A receptors (excluding pseudogenes) are still considered orphans; information has been provided where there is a significant phenotype in genetically modified animals. In class B, six pairings have been reported by a single publication, with 28 (excluding pseudogenes) still classified as orphans. Seven orphan receptors remain in class C, with one pairing described by a single paper. The objective is to stimulate research into confirming pairings of orphan receptors where there is currently limited information and to identify cognate ligands for the remaining GPCRs. Further information can be found on the IUPHAR Database website (http://www.iuphar-db.org).
Chido Mpamhanga's Skills & Expertise
Chido Mpamhanga's Education
The University of Sheffield
PhD, MSc, Computational Chemistry/Chemoinformatics
2002 – 2006
Chido Mpamhanga's Additional Information
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